Abstract
Two new steroidal saponins, diosbulbisides D (1 ) and E (2 ), along with five known saponins (3 –7 ) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7 , two 3-O -trisaccharides of diosgenin spirostanes, showed moderate cytotoxic activity against
human hepatocellular carcinoma cells, with IC50 values of 3.89 µM and 7.47 µM on SMMC7721, and 10.87 µM and 19.10 µM on Bel-7402
cell lines, respectively.
Key words
steroidal saponin -
Dioscorea bulbifera L. - Dioscoreaceae - cytotoxicity
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Prof. Dr. Zheng-Tao Wang
The MOE Key Laboratory for Standardization of Chinese Medicines Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine
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