Improved Microwave-Assisted Ring Opening of 1,1,1-Trifluoro-2,3-epoxypropane: Synthesis of New 3-Alkoxy-1,1,1-trifluoropropan-2-ols

Abstract

A highly efficient and environmentally friendly method for the synthesis of 3-alkoxy-1,1,1-trifluoropropan-2-ols is presented. The approach involves ring-opening reaction of 1,1,1-trifluoro-2,3-epoxypropane with structurally different long-chain alcohols under microwave irradiation at room temperature in the absence of solvent. These chemicals are precursors of the corresponding tri­fluoromethyl ketones, potent inhibitors of human and murine liver microsomes and porcine liver esterase.

Key words

1,1,1-trifluoro-2,3-epoxypropane - ring opening - tri­fluoro­methyl carbinols - trifluoromethyl ketones - microwave catalysis

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