An Efficient Synthesis of N′-(Fluoroalkylsulfonyl) Amidines
by a Copper(I)-Catalyzed One-Pot Three-Component Reaction

Wanting Xiong; Yong Xin; Jingwei Zhao; Shizheng Zhu

doi:10.1055/s-0030-1258450

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Synthesis 2011(7): 1142-1148
DOI: 10.1055/s-0030-1258450

PAPER

An Efficient Synthesis of N′-(Fluoroalkylsulfonyl) Amidines by a Copper(I)-Catalyzed One-Pot Three-Component Reaction

Wanting Xiong, Yong Xin, Jingwei Zhao, Shizheng Zhu*
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. of China
Fax: +86(21)64166128; e-Mail: zhusz@sioc.ac.cn;

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Publication History

Received 5 January 2011
Publication Date:
01 March 2011 (online)

Abstract
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Abstract

Fluoroalkylsulfonyl azides were successfully employed as an efficient reacting partner in copper(I)-catalyzed three-component couplings with terminal alkynes and amines to afford the corresponding N′-(fluoroalkylsulfonyl) amidines in good yields. Possible reaction pathways are proposed.

Key words

multicomponent reactions - fluoroalkylsulfonyl azides - 1-alkynes - amines - amidines

References

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