Combined Acid System for Asymmetric Addition of Boronates
to Chromene Acetals

doi:10.1055/s-0030-1258896

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Synfacts 2010(12): 1397-1397
DOI: 10.1055/s-0030-1258896

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Combined Acid System for Asymmetric Addition of Boronates to Chromene Acetals

Contributor(s): Hisashi Yamamoto, Patrick Brady
P. N. Moquist, T. Kodama, S. E. Schaus*
Boston University, USA

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Publikationsverlauf

Publikationsdatum:
22. November 2010 (online)

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Significance

The authors report a Lewis acid assisted chiral Brønsted acid system for the asymmetric addition of boronates to chromene acetals. The chromene products are obtained in good yields with high enantioselectivities. This method should prove to be useful in the synthesis of natural products.