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Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP
J. A. Johnson, Y. Y. Lu, A. O. Burts, Y. Xia, A. C. Durrell, D. A. Tirrell*, R. H. Grubbs*
California Institute of Technology, Pasadena, USA
16 February 2011 (online)
Recent advances showing the utility of ring-opening metathesis polymerization (ROMP) using catalyst 2 for the graft-through polymerization of a variety of norbornene-terminated macromonomers led to brush homo- and copolymers with high degrees of polymerization (DPs) and low polydispersity indices (PDIs). Hence, using catalyst 2 once more, the authors have synthesized the first example of bivalent-bottle-brush polymers 3 capable of simultaneous photoregulated release of anticancer drugs doxorubicin (DOX) and camptothecin (CT) with amazing ease via graft-through ROMP.