Synfacts 2011(3): 0266-0266  
DOI: 10.1055/s-0030-1259439
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP

Contributor(s): Timothy M. Swager, Joel Batson
J. A. Johnson, Y. Y. Lu, A. O. Burts, Y. Xia, A. C. Durrell, D. A. Tirrell*, R. H. Grubbs*
California Institute of Technology, Pasadena, USA
Further Information

Publication History

Publication Date:
16 February 2011 (online)


Recent advances showing the ­utility of ring-opening metathesis polymerization (ROMP) using catalyst 2 for the graft-through polymerization of a variety of norbornene-terminated macromonomers led to brush homo- and copolymers with high degrees of polymerization (DPs) and low polydispersity indices (PDIs). Hence, ­using catalyst 2 once more, the authors have ­synthesized the first example of bivalent-bottle-brush polymers 3 capable of simultaneous photoregulated release of anticancer drugs doxorubicin (DOX) and camptothecin (CT) with amazing ease via graft-through ROMP.