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Synthesis 2011(9): 1489-1493  
DOI: 10.1055/s-0030-1259990
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

An Efficient Synthesis of Pyrrolocoumarins and Pyrroloquinolones by Acid-Catalysed Cyclisation of Acetylenic Amines in Water

K. C. Majumdar*, Sudipta Ponra, Somjit Hazra, B. Roy
Department of Chemistry, University of Kalyani, Kalyani 741235, W. B, India
Fax: +91(33)25828282; e-Mail: kcm_ku@yahoo.co.in;
Further Information

Publication History

Received 15 December 2010
Publication Date:
04 April 2011 (online)

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Abstract

A simple H+-catalysed cyclisation of acetylenic amines for the synthesis of pyrrolocoumarins and pyrroloquinolones under conventional heating or microwave irradiation has been achieved. The reaction requires inexpensive catalyst and simple yet clean reaction conditions and offers potentially bioactive heterocycles in 82-95% yields.

Key words

pyrrolocoumarin - pyrroloquinolone - Brønsted acid catalysis - intramolecular cyclisation - microwave irradiation

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