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Synthesis 2011(13): 2117-2124
DOI: 10.1055/s-0030-1260058
DOI: 10.1055/s-0030-1260058
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkA Concise Total Synthesis of (S)-Zearalenone and Zeranol
Further Information
Received
25 March 2011
Publication Date:
26 May 2011 (online)
Publication History
Publication Date:
26 May 2011 (online)
Abstract
A convergent total synthesis of the naturally occurring, 14-membered macrolides (S)-zearalenone and zeranol has been achieved through application of the Diels-Alder reaction, Jacobsen kinetic resolution, Mitsunobu coupling, ring-closing metathesis, and hydrogenation as key steps.
Key words
Diels-Alder reaction - Jacobsen resolution - Mitsunobu reaction - ring-closing metathesis - macrolide
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