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Synthesis 2011(16): 2625-2628  
DOI: 10.1055/s-0030-1260105
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

The First Multicomponent Synthesis of Propargyl-1,2,3-triazoles [¹]

Biswanath Das*, Nisith Bhunia, Maram Lingaiah, Parigi Raghavendar Reddy
Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India
Fax: +91(40)27193198; e-Mail: biswanathdas@yahoo.com;
Further Information

Publication History

Received 15 April 2011
Publication Date:
14 July 2011 (online)

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Abstract

The three-component reaction of benzotriazoles, aldehydes, and alkynes has been carried out for the first time using zinc bromide as a catalyst. The corresponding propargylbenzotriazoles are formed in high yields (79-97%) within 6-10 hours.

Key words

propargyl-1,2,3-triazole - benzotriazole - aldehyde - alkyne - zinc bromide

1

Part 209 in the series ‘Studies on Novel Synthetic Methodologies.’

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1

Part 209 in the series ‘Studies on Novel Synthetic Methodologies.’