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Synthesis 2011(20): 3241-3246  
DOI: 10.1055/s-0030-1260188
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Trinitrogen-Containing Triheterocycles via the Intramolecular Nitrile Oxide Cycloaddition Reaction

Andrew J. Ferreira, Danielle M. Solano, James S. Oakdale, Mark J. Kurth*
Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA
e-Mail: mjkurth@ucdavis.edu;
Further Information

Publication History

Received 7 July 2011
Publication Date:
24 August 2011 (online)

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Abstract

The intramolecular nitrile oxide cycloaddition (INOC) reaction is applied to the synthesis of novel isoxazolooxazepinoindazole, benzoisoxazolodiazepinoindazolone, and spiro[isoxazoloazepine]piperidine heterocycles. Each of these targets incorporates a unique trinitrogen-containing triheterocyclic framework.

Keywords

alkenes - cycloadditions - heterocycles - pericyclic reactions - spiro compounds

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