Synthesis of (-)-Actinonin

Abstract

Synthesis of (-)-actinonin in 17% overall yield was accomplished in seven steps via the formation of an isoimide derivative as the key intermediate. The synthesis was carried out using commercially available dimethyl maleate without the use of a highly expensive reagent.

Key words

actinonin - PDF inhibitor - antibacterial agent - total synthesis - catalytic hydrogenation

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