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Flow Synthesis of Alkaloids
E. Riva, A. Rencurosi, S. Gagliardi, D. Passarella, M. Martinelli*
NiKem Research Srl, Baranzate and Università degli Studi di Milano, Italy
20 July 2011 (online)
A five-step continuous-flow synthesis of (+)-dumetorine 7 was described. A novel PEG-supported Hoveyda catalyst 10 was applied in the ring-closing metathesis, which was reused six times without significant loss of its catalytic activity in the model reaction.