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Copper-Catalyzed 1,4-Addition of Organo-boronates to Alkylidene Cyanoacetates
K. Takatsu, R. Shintani, T. Hayashi*
Kyoto University, Japan
20 July 2011 (online)
The authors report on a mild copper/N-heterocyclic carbene (NHC) catalyzed 1,4-addition of organoboronates to alkylidene cyanoacetates. Employing a newly synthesized chiral NHC ligand gives access to a broad range of enantiomerically enriched 1,4-adducts. However, it should be mentioned that different activating groups as EWG or CN afforded the corresponding products in lower yields.