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Synthesis of Chiral Furans by a Copper-Catalyzed Domino Process
V. Rauniyar, Z. J. Wang, H. E. Burks, F. D. Toste*
University of California, Berkeley, USA
20 July 2011 (online)
Cycloisomerization reactions allow complex molecules to be constructed in a manner which avoids stoichiometric waste products. The authors present a domino reaction whereby substituted enones cyclize to form cationic furans, which subsequently undergo asymmetric attack from indole nucleophiles.