Synfacts 2011(8): 0877-0877  
DOI: 10.1055/s-0030-1260743
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Friedel-Crafts Alkylation of Indoles Catalyzed by a Chiral Palladium Complex

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
Y. K. Kang, K. H. Suh, D. Y. Kim*
Soonchunhyang University, Asan, Korea
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20. Juli 2011 (online)


The authors developed a chiral palladium complex to promote the enantioselective Friedel-Crafts reaction of indoles with β,γ-unsaturated α-keto phosphonates. The reaction proceeds in good yield and enantioselectivities.