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Asymmetric Aza-Darzens Reaction Catalyzed by Mg Phosphate Salt
S. E. Larson, G. L. Li, G. B. Rowland, D. Junge, R. C. Huang, H. L. Woodcock, J. C. Antilla*
University of South Florida, Tampa, Mississippi State University, USA and Sun Yat-Sen University, Guangzhou, P. R. of China
20 July 2011 (online)
Chiral magnesium-VAPOL phosphate salt was successfully employed as a catalyst for the asymmetric aza-Darzens reaction through the addition of α-chloro-1,3-dicarbonyl compounds. The corresponding aziridines are obtained with good yields and enantioselectivities.