Synfacts 2011(8): 0878-0878  
DOI: 10.1055/s-0030-1260830
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Domino Synthesis of N-Sulfonylamidines

Contributor(s): Mark Lautens, Jane Panteleev
M. Yao, C.-D. Lu*
Xinjiang Technical Institute of Physics & Chemistry, Urumqi, P. R. of China
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Publication History

Publication Date:
20 July 2011 (online)


The authors describe a selective three-component synthesis of amidines 4. These synthons find a lot of applications in coordination and medicinal chemistry, and the development of new synthetic strategies towards them can be important. This protocol provides the products in high yields with excellent diastereo- and enantio­selectivities. The scope is broad with respect to N-tert-butylsulfinyl aldimines 3, and the reaction can be performed on gram scale.