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Synlett 2011(13): 1845-1848  
DOI: 10.1055/s-0030-1260953
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Sweet and Salted: Sugars Meet Hydroxyapatite

Monica Sandria, Antonino Natalellob, Davide Binib, Luca Gabriellib, Laura Cipolla*b, Francesco Nicotra*b
a Institute of Science and Technology for Ceramics - National Research Council, via Granarolo 64, 48018 Faenza, Italy
b Dept. of Biotechnology and Biosciences, University of Milano-Bicocca, P.za della scienza 2, 20126 Milano, Italy
Fax: +39(2)64483565; e-Mail: laura.cipolla@unimib.it; e-Mail: francesco.nicotra@unimib.it;
Further Information

Publication History

Received 12 May 2011
Publication Date:
14 July 2011 (online)

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Abstract

Carbonated hydroxyapatite (CHA) has been successfully biodecorated with carbohydrate derivatives, via silylation of the hydroxy groups of the apatite and subsequent covalent bonding with a suitably functionalized carbohydrate moiety. The presented procedure opens the way toward covalent biofunctionalisation of CHA with carbohydrates.

Key words

carbohydrates - C-glycosides - biomaterials - hydroxy­apatite - biofunctionalisation

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