Planta Med 2011; 77(11): 1203-1209
DOI: 10.1055/s-0030-1270832
Lectures GA Conference
Mini Reviews
© Georg Thieme Verlag KG Stuttgart · New York

Medicinal Plants from Jordan in the Treatment of Cancer: Traditional Uses vs. In vitro and In Vivo Evaluations – Part 1

Fatma U. Afifi-Yazar1 , Violet Kasabri1 , Rana Abu-Dahab1
  • 1Faculty of Pharmacy, University of Jordan, Amman, Jordan
Further Information

Publication History

received January 13, 2011 revised January 28, 2011

accepted February 2, 2011

Publication Date:
23 February 2011 (online)

Abstract

Plant species have long been used as principal ingredients in traditional medicine. Different surveys showed that ethnomedicinal plant species used by the inhabitants of Jordan for the treatment of cancer are inadequately screened for their therapeutic/chemopreventive potential and phytochemical findings. In this mini review, traditional herbal medicines pursued indigenously with their methods of preparation and active constituents are listed. Studies of random screening for selective cytotoxicity and antiproliferative activity of local spices, domesticated greens, or wild plants are briefly discussed. Recommended future directives for the design and conduct of comprehensive trials are pointed out to validate the usefulness of these active plants or bioactive phytoconstituents either alone or in combination with existing therapies or complementing pharmacologies.

References

  • 1 Al-Eisawi D, El-Oqlah A, Al-Khader I A. Jordan Country Study on Biological Diversity. United Nations Environmental Program, 2000. Amman; Al-Rai Commercial Press 2000: 7-11
  • 2 Al-Eisawi D M. List of Jordan vascular plants.  Mitt Bot München. 1982;  18 79-182
  • 3 Al-Eisawi D M. Vegetation of Jordan. Cairo; UNESCO-Regional Office for Science and Technology for the Arab States 1996: 266
  • 4 Al-Khalil S. A survey of plants used in Jordanian traditional medicine.  Int J Pharmacognosy. 1995;  33 317-323
  • 5 Azaizeh H, Fulder S, Khalil K, Said O. Ethnobotanical knowledge of local Arab practitioners in the Middle Eastern region.  Fitoterapia. 2003;  74 98-108
  • 6 Bonet M A, Valles J. Use of non-crop food vascular plants in Montseny biosphere reserve (Catalonia, Iberian Peninsula).  Int J Food Sci Nutr. 2002;  53 225-248
  • 7 Butler M S. The role of natural product chemistry in drug discovery.  J Nat Prod. 2004;  67 2141-2153
  • 8 Goldman P. Herbal medicines today and the roots of modern pharmacology.  Ann Intern Med. 2001;  135 594-600
  • 9 Phillipson J D. Phytochemistry and medicinal plants.  Phytochemistry. 2001;  56 237-243
  • 10 Newman D J, Cragg G M, Snader K M. Natural products as sources of new drugs over the period 1981–2001.  J Nat Prod. 2003;  66 1022-1037
  • 11 Abu-Rabia A. Herbs as a food and medicine source in Palestine.  Asian Pac J Cancer Prev. 2005;  6 404-407
  • 12 Nobili S, Lippi D, Witort E, Donnini M, Bausi L, Mini E, Capaccioli S. Natural compounds for cancer treatment and prevention.  Pharmacol Res. 2009;  59 365-378
  • 13 Afifi F U, Wazaify M, Jabr M, Treish E. The use of herbal preparations as complementary and alternative medicine (CAM) in a sample of patients with cancer in Jordan.  Complement Ther Clin Pract. 2010;  16 208-212
  • 14 Oran S A, Al-Eisawi D M. Check list of medicinal plants in Jordan.  Dirasat. 1998;  25 84-112
  • 15 Abu-Rmailah B, Afifi F. Treatment with medicinal plants in Jordan.  Dirasat. 2000;  27 53-74
  • 16 Al-Aboudi A, Afifi F U. Plants used for the treatment of diabetes in Jordan: A review of scientific evidence.  Pharm Biol. 2011;  49 221-239
  • 17 Camejo-Rodrigues J, Ascensao L, Bonet M A, Valles J. An ethnobotanical study of medicinal and aromatic plants in the Natural Park of “Serra de Sao Mamede” (Portugal).  J Ethnopharmacol. 2003;  89 199-209
  • 18 Jeambey Z, Johns T, Talhouk S, Batal M. Perceived health and medicinal properties of six species of wild edible plants in north-east Lebanon.  Public Health Nutr. 2009;  12 1902-1911
  • 19 Ali-Shtayeh M S, Yaniv Z, Mahajna J. Ethnobotanical survey in the Palestinian area: a classification of the healing potential of medicinal plants.  J Ethnopharmacol. 2000;  73 221-232
  • 20 Said O, Khalil K, Fulder S, Azaizeh H. Ethnopharmacological survey of medicinal herbs in Israel, the Golan Heights and the West Bank region.  J Ethnopharmacol. 2002;  83 251-265
  • 21 Hudaib M, Mohammad M, Bustanji Y, Tayyeb R, Yousef M, Aburjeie M, Aburjai T. Ethnopharmacological survey of medicinal plants in Jordan, Mujib Nature Reserve and surrounding area.  J Ethnopharmacol. 2008;  120 63-71
  • 22 Al-Qura'n S. Ethnopharmacological survey of wild medicinal plants in Showbak, Jordan.  J Ethnopharmacol. 2009;  123 45-50
  • 23 Talib W H, Mahasneh A M. Antiproliferative activity of plant extracts used against cancer in traditional medicine.  Sci Pharm. 2010;  78 33-45
  • 24 WHO .WHO projections of the global burden of disease including cancer: 2004–2030. http://www.who.int/healthinfo/global_burden_disease/projections/en/index.html Accessed January 1, 2011
  • 25 Tarawneh M, Nimri O. Cancer incidence in Jordan. Jordan Cancer Registry. Jordan; Ministry of Health 2007
  • 26 King Hussein Cancer Centre .Jordanian cancer statistics for the year 2007. Amman; KHCC publications 2007
  • 27 Abu-Dahab R, Afifi F. Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7).  Sci Pharm. 2007;  75 121-136
  • 28 Afifi-Yazar F U, Abu-Dahab R, Ismail S. Medicinal plants and anticancer activities: Experiences from Jordan using MCF7 cell lines. BIT Life Sciences' 1st Annual World Cancer Congress, Shanghai. 2008
  • 29 Abu-Dahab R, Afifi-Yazar F U. Comparison of antiproliferative activities of ethanolic plant extracts of the Jordanian flora using MCF7 and A549 cells.  Planta Med. 2007;  3 990
  • 30 Al-Kalaldeh J Z, Abu-Dahab R, Afifi F U. Volatile oil composition and antiproliferative activity of Laurus nobilis, Origanum syriacum, Origanum vulgare and Salvia triloba against human breast adenocarcinoma cells.  Nutr Res. 2010;  30 271-278
  • 31 Gupta M. Pharmacological properties and traditional therapeutic uses of important Indian spices: A review.  Int J Food Prop. 2010;  13 1092-1116
  • 32 Faris M A, Takruri H R, Shomaf M S, Bustanji Y K. Chemopreventive effect of raw and cooked lentils (Lens culinaris L.) and soybeans (Glcine max) against azoxymethane-induced aberrant crypt foci.  Nutr Res. 2009;  29 355-362
  • 33 Khataibeh M, Abu-Alruz K, Al-Widyan O, Abu-Samak M, Al-Qudah J. Combined supplementation of soy and garlic modulate biochemical parameters of 7,12-dimethylbenz[alpha]anthracene induced mammary cancer in female albino rats.  Pakistan J Biol Res. 2007;  10 2308-2313
  • 34 Abuherfeil N M, Maraqa A, Von Kleist S. Augmentation of natural killer cell activity in vitro against tumour cells by some wild plants from Jordan.  J Ethnopharmacol. 2000;  71 55-63
  • 35 Shabsoug B, Khalil R, Abuherfeil N. Enhancement of natural killer cell activity in vitro against human tumour cells by some plants from Jordan.  J Immunotoxicol. 2008;  5 279-285
  • 36 Abuherfeil N M, Salim M, Von Kleist S. Augmentation of natural killer cell activity in vivo against tumour cells by some wild plants from Jordan.  Phytother Res. 2001;  15 109-113
  • 37 Fiore G, Nencini C, Cavallo F, Capasso A, Bader A, Giorgi G, Micheli L. In vitro antiproliferative effect of six Salvia species on human tumor cell lines.  Phytother Res. 2006;  20 701-703
  • 38 Kaileh M, Berghe W V, Boone E, Essawi T, Haegeman G. Screening of indigenous Palestinian plants for potential anti-inflammatory and cytotoxic activity.  J Ethnopharmacol. 2007;  113 510-516
  • 39 Kaileh M, Vanden Berghe W, Heyerick A, Horion J, Piette J, Libert C, De Keukeleire D, Essawi T, Haegeman G. Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.  J Biol Chem. 2007;  282 4253-4264
  • 40 Alali F Q, El-Elimat T, Li C, Qandil A, Alkofahi A, Tawaha K, Burgess J P, Nakanishi Y, Kroll D J, Navarro H A, Falkinham III J O, Wani M C, Oberlies N H. New colchicinoids from a native Jordanian meadow saffron, Colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.  J Nat Prod. 2005;  68 173-178
  • 41 Alali F, Ma'aya'h A S, Alkofahi A, Qandil A, Li C, Burgess J P, Wani M C, Oberlies N H. A new colchicinoid from Colchicum tauri, an unexplored meadow saffron native to Jordan.  Nat Prod Commun. 2006;  1 95-99
  • 42 Alali F, Tawaha K, El-Elimat T, Qassaymeh R, Li C, Burgess J P, Yuka N, Kroll D J, Wani M C, Oberlies N Hl. Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons.  Nat Prod Res. 2006;  20 558-566
  • 43 Alali F Q, Gharaibeh A, Ghawanmeh A, Tawaha K, Oberlies N H. Colchicinoids from Colchicum crocifolium Boiss.: a case study in dereplication strategies for (−)-colchicine and related analogues using LC-MS and LC-PDA techniques.  Phytochem Anal. 2008;  19 385-394
  • 44 Al-Mahmoud M S, Alali F Q, Tawaha K, Qasaymeh R M. Phytochemical study and cytotoxicity evaluation of Colchicum stevenii Kunth (Colchicaceae): a Jordanian meadow saffron.  Nat Prod Res. 2006;  20 153-160
  • 45 Alali F Q, Gharaibeh A A, Ghawanmeh A, Tawaha K, Qandil A, Burgess J P, Sy A, Nakanishi Y, Kroll D J, Oberlies N H. Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae).  Nat Prod Res. 2010;  24 152-159
  • 46 Alali F Q, Tahboub Y R, Ibrahim E S, Qandil A M, Tawaha K, Burgess J P, Sy A, Nakanishi Y, Kroll D J, Oberlies N H. Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae).  Phytochemistry. 2008;  69 2341-2346
  • 47 Rates S M K. Plants as source of drugs.  Toxicon. 2001;  39 603-613
  • 48 Dorai T, Aggarwal B B. Role of chemopreventive agents in cancer therapy.  Cancer Lett. 2004;  215 129-140
  • 49 Rabi T, Bishayee A. Terpenoids and breast cancer chemoprevention.  Breast Cancer Res Treat. 2009;  115 223-239
  • 50 Pezzuto J M. Resveratrol as an inhibitor of carcinogenesis.  Pharm Biol. 2008;  46 443-573
  • 51 Amin A R, Kucuk O, Khuri F R, Shin D M. Perspectives for cancer prevention with natural compounds.  J Clin Oncol. 2009;  27 2712-2715
  • 52 Kasinski A L, Du Y, Thomas S L, Zhao J, Sun S Y, Khuri F R, Wang C Y, Shoji M, Sun A, Snyder J P, Liotta D, Fu H. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis (2-flurobenzylidene) piperidin-4-one (EF24), a novel monoketone analog of curcumin.  Mol Pharmacol. 2008;  74 654-661
  • 53 Rajabalian S. Methanolic extract of Teucrium polium L. potentiates the cytotoxic and apoptotic effects of anticancer drugs of vincristine, vinblastine and doxorubicin against a panel of cancerous cell lines.  Exp Oncol. 2008;  30 133-138
  • 54 Sarkar F H, Li Y. Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics.  Cancer Treat Rev. 2009;  35 597-607
  • 55 Papas T S, Sandhaus L, Chirigos M A, Furusawa E. Inhibition of DNA polymerase of avian myeloblastosis virus by an alkaloid extract from Narcissus tazetta L.  Biochem Biophys Res Commun. 1973;  52 88-92
  • 56 Youssef D T, Khalifa A A. Cytotoxic quaternary alkaloids from the flowers of Narcissus tazetta.  Pharmazie. 2001;  56 818-822
  • 57 Talib W H, Mahasneh A M. Antimicrobial, cytotoxicity and phytochemical screening of Jordanian plants used in traditional medicine.  Molecules. 2010;  15 1811-1824
  • 58 Kelling C L, Schipper I A, Schermeister L J, Vacik J P. Effects of crude extracts of various plants on infectious bovine rhinotracheitis virus-plaque production.  Am J Vet Res. 1976;  37 215-218
  • 59 Ooi L S, Tian L, Su M, Ho W S, Sun S S, Chung H Y, Wong H N, Ooi V E. Isolation, characterisation, molecular cloning and modelling of a new lipid transfer protein with antiviral and antiproliferative activities from Narcissus tazetta.  Peptides. 2008;  29 2101-2109
  • 60 Khalil A, Dababneh B. Inhibition of phytopathogenic fungi by extracts from medicinal plants in Jordan.  J Biol Sci. 2007;  7 579-581
  • 61 El-Desouky S K, Kim K H, Ryu S Y, Eweas A F, Gamal-Eldeen A M, Kim Y K. A new pyrrole alkaloid isolated from Arum palaestinum Boiss. and its biological activities.  Arch Pharm Res. 2007;  30 927-931
  • 62 Al-Mustafa A H, Al-Thunibat O Y. Antioxidant capacity of some Jordanian medicinal plants used traditionally for the treatment of diabetes.  Pakistan J Biol Sci. 2008;  11 351-358
  • 63 Majester-Savornin B, Elias R, Diaz-Lanza A M, Balansard G, Gasquet M, Delmas F. Saponins of the ivy plant, Hedera helix, and their leishmanicidic activity.  Planta Med. 1991;  57 260-262
  • 64 Demirci B, Goppel M, Demirci F, Franz G. HPLC profiling and quantification of active principles in leaves of Hedera helix L.  Pharmazie. 2004;  59 770-774
  • 65 Facino R M, Carini M, Stefani R, Aldini G, Saibene L. Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency.  Arch Pharm (Weinheim). 1995;  328 720-724
  • 66 Trute A, Gross J, Mutschler E, Nahrstedt A. In vitro antispasmodic compounds of the dry extract obtained from Hedera helix.  Planta Med. 1997;  63 125-129
  • 67 Elias R, De Meo M, Vidal-Ollivier E, Laget M, Balansard G, Dumenil G. Antimutagenic activity of some saponins isolated from Calendula officinalis L., C. arvensis L. and Hedera helix L.  Mutagenesis. 1990;  5 327-331
  • 68 Hofmann D, Hecker M, Volp A. Efficacy of dry extract of ivy leaves in children with bronchial asthma–a review of randomised controlled trials.  Phytomedicine. 2003;  10 213-220
  • 69 Zarga M H, Sabri S S, Hamed E M, Khanfar M A, Zeller K P, Atta-Ur-Rahman. A new eudesmane type sesquiterpene from Inula viscosa.  Nat Prod Res. 2003;  17 99-102
  • 70 Lauro L, Rolih C. Observations and research on an extract of Inula viscosa Ait.  Boll Soc Ital Biol Sper. 1990;  66 829-834
  • 71 Al-Dissi N M, Salhab A S, Al-Hajj H. Effects of Inula viscosa leaf extracts on abortion and implantation in rats.  J Ethnopharmacol. 2001;  77 117-121
  • 72 Askin Celik T, Aslanturk O S. Evaluation of cytotoxicity and gentoxicity of Inula viscosa leaf extracts with Allium test.  J Biomed Biotechnol. DOI: 10.1155/2010/189252 , advance online publication 23 June 2010;
  • 73 Zeggwagh N A, Ouahidi M L, Lemhadri A, Eddouks M. Study of hypoglycaemic and hypolidemic effects of Inula viscosa L. aqueous extract in normal and diabetic rats.  J Ethnopharmacol. 2006;  108 223-227
  • 74 Chemli R, Toumi A, Queslati S, Zouaghi H, Boukef K, Balansard G. Calendula arvensis L. Impact of saponins on toxicity, haemolytic effect and anti-inflammatory activity.  J Pharm Belg. 1990;  45 12-16
  • 75 De Tommasi N, Pizza C, Conti C, Orsi N, Stein M L. Structure and in vitro antiviral activity of sesquiterpene glycosides from Calendula arvensis.  J Nat Prod. 1990;  53 830-835
  • 76 Saleh M M, Rizk A M. Flavonoids and coumarins of Anthemis pseudocotiola.  Planta Med. 1974;  25 60-62
  • 77 Yoshikawa K, Arihara S, Wang J D, Narui T, Okuyama T. Structures of two fibrinolytic saponins from seeds of Luffa cylindrica Roem.  Chem Pharm Bull. 1991;  39 1185-1188
  • 78 Khajuria A, Gupta A, Garai S, Wakhloo B P. Immunomodulatory effects of two saponins 1 and 2 isolated from Luffa cylindrica in Balb/C mice.  Bioorg Med Chem Lett. 2007;  17 1608-1612
  • 79 Du Q, Cui H. A new flavone glycoside from the fruits of Luffa cylindrica.  Fitoterapia. 2007;  78 609-610
  • 80 Ng T B, Chan W Y, Yeung H W. Proteins with abortifacient, ribosome inactivating, immunomodulatory, antitumor and anti-AIDS activities from Cucurbitaceae plants.  Gen Pharmacol. 1992;  23 579-590
  • 81 Ng T B, Wong R N, Yeung H W. Two proteins with ribosome-inactivating, cytotoxic and abortifacient activities from seeds of Luffa cylindrica roem (Cucurbitaceae).  Biochem Int. 1992;  27 197-207
  • 82 Du Q, Xu Y, Li L, Zhao Y, Jerz G, Winterhalter P. Antioxidant constituents in the fruits of Luffa cylindrica (L.) Roem.  J Agric Food Chem. 2006;  54 4186-4190
  • 83 Poma A, Marcozzi G, Cesare P, Carmignanu M, Spano L. Antiproliferative effect and apoptotic response in vitro of human melanoma cells to liposomes containing the ribosome-inactivating protein luffin.  Biochim Biophys Acta. 1999;  1472 197-205
  • 84 Lui L, Wang R, He W, He F, Huang G. Cloning and soluble expression of mature alpha-luffin from Luffa cylindrica and its antitumor activities in vitro.  Acta Biochim Biophys Sin (Shanghai). 2010;  42 585-592
  • 85 Issa R A, Afifi F U, Amro B I. Studying the anti-tyrosinase effect of Arbustus andrachne L. extracts.  Int J Cosmet Sci. 2008;  40 271-276
  • 86 Dumkow K. Flavonoids of domestic euphorbiaceae. 4. Flavonol glycosides of Mercurialis annua L.  Z Naturforsch B. 1969;  24 1203
  • 87 Hanus L O, Temina M, Dembitsky V. Biodiversity of the chemical constituents in the epiphytic lichenized ascomycete Ramalina lacera grown on difference substrates Crataegus sinaicus, Pinus halepensis, and Quercus calliprinos.  Biomed Pap. 2008;  152 203-208
  • 88 Yeruham I, Avidar Y, Perl S, Yakobson B, Shlosberg A, Hanji V, Bogin E. Probable toxicosis in cattle in Israel caused by the oak Quercus calliprinos.  Vet Hum Toxicol. 1998;  40 336-340
  • 89 Elbetieha A, Oran S A, Alkofahi A, Darmnai H, Raies A M. Fetotoxic potentials of Globularia arabica and Globularia alypum (Globulariaceae) in rats.  J Ethnopharmcol. 2000;  72 215-219
  • 90 Oran S A, Raies A M. Antimicrobial activity of Globularia arabica Jaub. and Spach and G. alypum L. (Globulariaceae).  Dirasat. 2000;  27 71-73
  • 91 Sultan M M, Zaki A K. Antiviral screening of forty-two Egyptian medicinal plants.  J Ethnopharmcol. 2009;  126 102-107
  • 92 Dall'Aqua S, Cervellati R, Speroni E, Costa S, Guerra M C, Stella L, Greco E, Innocenti G. Phytochemical composition and antioxidant activity of Laurus nobilis L. leaf infusion.  J Med Food. 2009;  12 869-876
  • 93 Ferreira A, Proenca C, Serralheiro M L, Araujo M E. The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal.  J Ethnopharmacol. 2006;  108 31-37
  • 94 Panza E, Tersigni M, Iorizzi M, Zollo F, De Marino S, Festa C, Napolitano M, Castello G, Ialenti A, Ianaro A. Lauroside B, a megastigmane glycoside from Laurus nobilis (Bay Laurel) leaves, induces apoptosis in human melanoma cell lines by inhibiting NF-κB activation.  J Nat Prod. DOI: 10.1021/np100688g , advance online publication 28 December 2010;
  • 95 Innocenti G, Dall'Acqua S, Viola G, Loi M C. Cytotoxic constituents from Anagyris foetida leaves.  Fitoterapia. 2006;  77 595-597
  • 96 Dias C, Borralho Graca J A, Lurdes Goncalves M. Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts.  J Ethnopharmacol. 2000;  71 487-492
  • 97 Krenn L, Jelovina M, Kopp B. New bufadienolides from Urginea maritime sensu strictu.  Fitoterapia. 2000;  71 126-129
  • 98 Civelek H S, Weintraub P G. Effects of two plant extracts on larval leafminer Liriomyza trifolii (Diptera: Agromyzidae) in tomatoes.  J Econ Entomol. 2004;  97 1581-1586
  • 99 Mert M, Betul B. Cytogenetic effects of Urginea maritime L. aqueous extracts on the chromosomes by using Allium test method.  Caryologia. 2008;  61 342-348
  • 100 Boyle S P, Dobson V L, Duthie S J, Kyle J A, Collins A R. Absorption and DNA protective effects of flavonoid glycosides from an onion meal.  Eur J Nutr. 2000;  39 213-223
  • 101 Griffiths G, Trueman L, Crowther T, Thomas B, Smith B. Onions—a global benefit to health.  Phytother Res. 2002;  16 603-615
  • 102 Rose P, Whiteman M, Moore P K, Zhu Y Z. Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium: the chemistry of potential therapeutic agents.  Nat Prod Rep. 2005;  22 351-368
  • 103 Galluzzo P, Martini C, Bulzomi P, Leone S, Bolli A, Pallottini V, Marino M. Quercetin-induced apoptotic cascade in cancer cells: antioxidant versus estrogen receptor alpha-dependent mechanisms.  Mol Nutr Food Res. 2009;  53 699-708
  • 104 El-Aasr M, Fujiwara Y, Takeya M, Ikeda T, Tsukamoto S, Ono M, Nakano D, Okawa M, Kinjo J, Yoshimitsu H, Nohara T. Onionin A from Allium cepa inhibits macrophage activation.  J Nat Prod. 2010;  73 1306-1308
  • 105 Srinivasan K. Plant foods in the management of diabetes mellitus: spices as beneficial antidiabetic food adjuncts.  Int J Food Sci Nutr. 2005;  56 399-414
  • 106 Hubbard G P, Wolffram S, de Vos R, Bovy A, Gibbins J M, Lovegrove J A. Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study.  Br J Nutr. 2006;  96 482-488
  • 107 Sengupta A, Ghosh S, Bhattacharjee S. Allium vegetables in cancer prevention: an overview.  Asian Pac J Cancer Prev. 2004;  5 237-245
  • 108 González C A, Pera G, Agudo A, Bueno-de-Mesquita H B, Ceroti M, Boeing H, Schulz M, Del Giudice G, Plebani M, Carneiro F, Berrino F, Sacerdote C, Tumino R, Panico S, Berglund G, Simán H, Hallmans G, Stenling R, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quiros J R, Allen N, Key T J, Bingham S, Day N E, Linseisen J, Nagel G, Overvad K, Jensen M K, Olsen A, Tjønneland A, Büchner F L, Peeters P H, Numans M E, Clavel-Chapelon F, Boutron-Ruault M C, Roukos D, Trichopoulou A, Psaltopoulou T, Lund E, Casagrande C, Slimani N, Jenab M, Riboli E. Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).  Int J Cancer. 2006;  118 2559-2566
  • 109 Galasso R, Palli D, Tumino R, Vineis P, Trichopoulou A, Kalapothaki V, Trichopoulos D, Chang-Claude J, Linseisen J, Boutron-Ruault M C, Touillaud M, Clavel-Chapelon F, Olsen A, Tjønneland A, Overvad K, Tetsche M, Jenab M, Norat T, Kaaks R, Riboli E. Fruit and vegetable consumption and risk of epithelial ovarian cancer: the European Prospective Investigation into Cancer and Nutrition.  Cancer Epidemiol Biomarkers Prev. 2005;  14 253-255
  • 110 Galeone C, Pelucchi C, Dal Maso L, Negri E, Montella M, Zucchetto A, Talamini R, La Vecchia C. Allium vegetables intake and endometrial cancer risk.  Public Health Nutr. 2009;  12 1576-1579
  • 111 Ban J O, Hwang I G, Kim T M, Hwang B Y, Lee U S, Jeong H S, Yoon Y W, Kimz D J, Hong J T. Anti-proliferate and pro-apoptotic effects of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyranone through inactivation of NF-kappaB in human colon cancer cells.  Arch Pharm Res. 2007;  30 1455-1463
  • 112 Shrivastava S, Ganesh N. Tumour inhibition and cytotoxicity assay by aqueous extract of onion (Allium cepa) & garlic (Allium sativum): an in-vitro analysis.  Int J Phytomed. 2010;  2 80-84
  • 113 Martin-Cordero C, Lopez-Lazaro M, Agudo M A, Navarro E, Trujillo J, Ayus M J. A cytotoxic diarylheptanoid from Viscum cruciatum.  Phytochemistry. 2001;  58 567-569
  • 114 Hass K, Bauer M, Wollenweber E. Cuticular waxes and flavonol aglycones of mistletoes.  Z Naturforsch. 2003;  58 464-470
  • 115 Alali F Q, Tawaha K, El-Elimat T, Syouf M, Al-Fayad M, Abulaila K, Nielsen S J, Wheaton W D, Falkinham 3rd J O, Oberlies N H. Antioxidant activity and total phenolic content of aqueous and methanolic extracts of Jordanian plants: an ICBG project.  Nat Prod Res. 2007;  21 1121-1131
  • 116 Saenz M T, Ahumada M C, Garcia M D. Extracts from Viscum and Crataegus are cytotoxic against larynx cancer cells.  Z Naturforsch. 1997;  52 42-44
  • 117 Hussain S F, Khan L, Guinaudeau H, Leet J E, Freyer A J, Shamma M. The alkaloidal profile of Cocculus pendulus.  Tetrahedron. 1984;  40 2513-2517
  • 118 Atta-ur-Rahman. Isolation, structural and synthetic studies on the chemical constituents of medicinal plants of Pakistan.  Pure Appl Chem. 1986;  58 663-673
  • 119 Al-Khalil S, Al-Eisawi D, Sharaf M, Schiff Jr P L. Alkaloids of Cocculus pendulus.  Planta Med. 1993;  59 276
  • 120 Atta-ur-Rahman, Atia-Tul-Wahab, Nawaz S A, Choudhary I M. New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Cocculus pendulus.  Chem Pharm Bull (Tokyo). 2004;  52 802-806
  • 121 Atta-ur-Rahman, Atia-Tul-Wahab, Zia Sultani S, Nawaz S A, Choudhary I M. Bisbenzylisoquinoline alkaloids from Cocculus pendulus.  Nat Prod Res. 2009;  23 1265-1273
  • 122 Qu H, Madl R L, Takemoto D J, Baybutt R C, Wang W. Lignans are involved in the antitumor activity of wheat bran in colon cancer SW480 cells.  J Nutr. 2005;  135 598-602
  • 123 Borowicki A, Stein K, Scharlau D, Glei M. Fermentation supernatants of wheat (Triticum aestivum L.) aleurone beneficially modulate cancer progression in human colon cells.  J Agric Food Chem. 2010;  58 2001-2007
  • 124 Mitrokotsa D, Mitaku S, Demetzos C, Harvala C, Mentis A, Perez S, Kokkinopoulos D. Bioactive compounds from the buds of Plantanus orientalis and isolation of a new kaempferol glycoside.  Planta Med. 1993;  59 517-520
  • 125 Dimas K, Demetzos C, Mitaku S, Marselos M, Tzavaras T, Kokkinopoulos D. Cytotoxic activity of kaempferol glycoside against human leukaemic cell lines in vitro.  Pharmacol Res. 2000;  41 85-88
  • 126 Atmani D, Chaher N, Berboucha M, Ayouni K, Lounis H, Boudaoud H. Antioxidant capacity and phenol content of selected Algerian medicinal plants.  Food Chem. 2009;  112 303-309
  • 127 Dafni A, Levy S, Lev E. The ethnobotany of Christ's Thorne jujube (Ziziphus spina-christi) in Israel.  J Ethnobiol Ethnomed. 2005;  1 8
  • 128 Saied A S, Gebauer J, Hammer K, Buerkert A. Ziziphus spina-christi (L.) Willd: a multipurpose fruit tree.  Genet Resour Crop Evol. 2008;  55 929-937
  • 129 El-Din Hussein Mahran G, Glombitza K W, Mirhom Y W, Hartmann R, Michel C G. Novel saponins from Zizyphus spina-christi growing in Egypt.  Planta Med. 1996;  62 163-165
  • 130 Shahat A A, Pieters L, Apers S, Nazeif N M, Abdel-Azim N S, Berghe D V, Vlietinck A J. Chemical and biological investigations on Zizyphus spina-christi L.  Phytother Res. 2001;  15 593-597
  • 131 Abdel-Zaher A O, Salim S Y, Assaf M H, Abdel-Hady R H. Antidiabetic activity and toxicity of Zizyphus spina-christi leaves.  J Ethnopharmacol. 2005;  101 129-138
  • 132 Nesseem D I, Michel C G, Sleem A A, Al-Alfy T S. Formulation and evaluation of antihyperglycemic leaf extracts of Zizyphus spina-christi (L.) Willd.  Pharmazie. 2009;  64 104-109
  • 133 Michel C G, Nesseem D I, Ismail M F. Anti-diabetic activity and stability study of the formulated leaf extract of Zizyphus spina-christi (L.) Willd with the influence of seasonal variation.  J Ethnopharmacol. 2011;  133 53-62
  • 134 Abdel-Wahhab M A, Omara E A, Abdel-Galil M M, Hassan N S, Nada S A, Saeed A, el-Sayed M M. Zizyphus spina-christi extract protects against aflatoxin B1-initiated hepatic carcinogenicity.  Afr J Tradit Complement Alternat Med. 2007;  4 248-256
  • 135 Amin A, Mahmoud-Ghoneim D. Zizyphus spina-christi protects against carbon tetrachloride-induced liver fibrosis in rats.  Food Chem Toxicol. 2009;  47 2111-2119
  • 136 Godini A, Kazem M, Naseri G, Badavi M. The effect of Ziziphus spina-christi leaf extract on isolated rat aorta.  JPMA. 2009;  53 537-539
  • 137 Hadizadeh I, Peivastegan B, Kolahi M. Antifungal activity of nettle (Urtica dioica L.), colocynth (Citrullus colocynthis L. Schrad), oleander (Nerium oleander L.) and konar (Ziziphus spina-christi L.) extracts on plants pathogenic fungi.  Pakistan J Biol Sci. 2009;  12 58-63
  • 138 Reher G, Reznicek G, Baumann A. Triterpenoids from Sarcopoterium spinosum and Sanguisorba minor.  Planta Med. 1991;  57 506
  • 139 Kasabri V, Afifi F U, Hamdan I. In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine.  J Ethnopharmacol. 2011;  27 888-896
  • 140 Smirin P, Taler D, Abitbol G, Brutman-Barazani T, Kerem Z, Sampson S R, Rosenzweig T. Sarcopoterium spinosum extract as an antidiabetic agent: in vitro and in vivo study.  J Ethnopharmacol. 2010;  129 10-17
  • 141 Bashri-Sahloul R, Ammar S, Fredj R B, Saguem S, Grec S, Trotin F, Skhiri F H. Polyphenol contents and antioxidative activities of extracts from flowers of two Crataegus azarolus L. varieties.  Pakistan J Biol Sci. 2009;  12 660-668
  • 142 Ozen T, Collu Z, Korkmaz H. Antioxidant properties of Urtica pilulifera root, seed, flower and leaf extract.  J Med Food. 2010;  13 1224-1231
  • 143 Kavalali G, Tuncel H, Goksel S, Hatemi H H. Hypoglycaemic activity of Urtica pilulifera in streptozotocin-diabetic rats.  J Ethnopharmacol. 2003;  84 241-245

Prof. Dr. Fatma U. Afifi-Yazar

Department of Pharmaceutical Sciences
Faculty of Pharmacy
University of Jordan

Queen Rania Al-Abdullah Street

Amman 11942

Jordan

Phone: +96 2 65 35 50 00 ext. 23 3 01

Fax: +96 2 65 30 02 50

Email: fatueafi@ju.edu.jo

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