Abstract
An anticancer-bioassay guided isolation of the ethanol extract and fractions of two
plants from the Peruvian rainforest, Mikania decora and Cremastosperma microcarpum , led to the characterization of one abundant diterpene, ent -pimara-8(14),15-dien-19-oic acid (1 ), three thymol derivatives, 10-acetoxy-8,9-dehydro-6-methoxythymol butyrate (2 ), 10-acetoxy-8,9-epoxy-6-methoxythymol isobutyrate (3 ), and acetylschizoginol (4 ), as well as one neolignan, (±)-trans -dehydrodiisoeugenol (5 ). Only the latter was isolated from C. microcarpum . These compounds exhibited significant cytotoxic activity against a panel of human
tumor cell lines. Compounds 3 and 4 were also investigated for their in vitro antileishmanial and trypanocidal activity against Leishmania amazonensis axenic amastigotes and Trypanosoma cruzi trypomastigotes.
Key words
Mikania decora
- Compositae -
Cremastosperma microcarpum – Annonaceae - anticancer - antileishmania - trypanoside
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Univ.-Prof. Dr. Gerald B. Hammond
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