Planta Med 2011; 77(15): 1730-1734
DOI: 10.1055/s-0030-1271045
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Cardenolide Glycosides from the Seeds of Antiaris toxicaria

Wen-Hua Dong1 , 2 , Wen-Li Mei1 , 2 , You-Xing Zhao1 , 2 , Yan-Bo Zeng1 , 2 , Wen-Jian Zuo1 , 2 , Hui Wang1 , 2 , Xiao-Na Li1 , 2 , Hao-Fu Dai1 , 2
  • 1Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, P. R. China
  • 2Haikou Key Laboratory for Research and Development of Tropical Natural Products, Haikou, Hainan, P. R. China
Further Information

Publication History

received March 14, 2011 revised March 14, 2011

accepted April 1, 2011

Publication Date:
20 April 2011 (eFirst)

Abstract

Bioassay-guided fractionation of the ethanolic extract from the seeds of Antiaris toxicaria led to the isolation of three new cardiac glycosides named toxicarioside J (1), toxicarioside K (2), and toxicarioside L (3), together with a known glucostrophalloside (4). The structures of the new compounds were elucidated by spectroscopic methods including HRESIMS, UV, IR, and 1D, 2D NMR techniques. The cytotoxic activities of these cardiac glycosides against human gastric (SGC-7901) and human hepatoma (SMMC-7721) cell lines were evaluated, and all of them exhibited significant cytotoxicity.

References

Prof. Dr. Hao-Fu Dai

Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine Institute of Tropical Bioscience and Biotechnology
Chinese Academy of Tropical Agricultural Sciences
Haikou Key Laboratory for Research and Development of Tropical Natural Products

4 Xueyuan Road, Longhua District

Haikou 571101 Hainan

P. R. China

Phone: +8 68 98 66 96 18 69

Fax: +8 68 98 66 96 18 69

Email: hfdai2001@yahoo.com.cn