Planta Med 2011; 77(15): 1739-1741
DOI: 10.1055/s-0030-1271064
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Two Pairs of Epimeric Indole Alkaloids from Catharanthus roseus

Guo-Cai Wang1 , 2 , Xiang-Zhan Zhong1 , 2 , Dong-Mei Zhang1 , 2 , Ying Wang1 , 2 , Xiao-Qi Zhang1 , 2 , Ren-Wang Jiang1 , 2 , Yao-Lan Li1 , 2 , Jiao Wang1 , 2 , Xin-Sheng Yao1 , 2 , Wen-Cai Ye1 , 2
  • 1Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
  • 2Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, P. R. China
Further Information

Publication History

received January 4, 2011 revised March 31, 2011

accepted April 7, 2011

Publication Date:
03 May 2011 (eFirst)

Abstract

Two pairs of epimeric indole alkaloids (14) with a chlorine atom were isolated from the aerial part of Catharanthus roseus. Their structures were established on the basis of the spectroscopic data including UV, IR, HRESIMS, NMR, and X-ray diffraction analyses. The cytotoxic activities of 14 against the HepG2 cell line were evaluated.

References

Prof. Dr. Wen-Cai Ye

Institute of Traditional Chinese Medicine and Natural Products
College of Pharmacy, Jinan University

No. 601 Huangpu Road West

Guangzhou 510632

P. R. China

Phone: +86 20 85 22 15 59

Fax: +86 20 85 22 15 59

Email: chywc@yahoo.com.cn