Planta Med 2011; 77(15): 1725-1729
DOI: 10.1055/s-0030-1271101
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Steroids from Sarcococca saligna

Yu-Xin Yan1 , 2 , Yun Sun1 , 2 , Jian-Chao Chen1 , Yuan-Yuan Wang1 , Yan Li1 , Ming-Hua Qiu1
  • 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
  • 2Graduate School of the Chinese Academy of Sciences, Beijing, P. R. China
Further Information

Publication History

received October 18, 2010 revised April 10, 2011

accepted April 18, 2011

Publication Date:
17 May 2011 (eFirst)

Abstract

Two new C21-steroidal esters, sarsaligates A (1) and B (2), and two new steroidal alkaloids, sarsaligenines A (3) and B (4), together with four known compounds (sarcovagine, sarcorucinine, dimethylamino-3β-pregnane-20-one, and β-sitosterol 58, respectively), were isolated from the leaves and stems of Sarcococca saligna. The structures of compounds 14 were elucidated by NMR and MS spectroscopic analysis. Of the compounds tested, 5 and 6 were the most cytotoxic against the cell lines K562, SK-BR-3, and PANC-1, with IC50 values in the range of 2.25–5.00 µM, while 3 and 4 selectively inhibited HL-60 cells with IC50 values of 2.87 and 3.61 µM, respectively. Compounds 36 therefore deserve further evaluation of their cytotoxic potentials.

Supporting Information

References

Ming-Hua Qiu

State Key Laboratory of Phytochemistry and Plant Resources in West China
Kunming Institute of Botany
Chinese Academy of Sciences

134 Lan-Hei Road

Kunming 650204

P. R. China

Phone: +86 87 15 22 33 27

Fax: +86 87 15 22 32 55

Email: mhchiu@mail.kib.ac.cn