Pd-Catalyzed Direct Alkynylation of Aliphatic C-H
Bonds

doi:10.1055/s-0031-1289194

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Synfacts 2011(11): 1223-1223
DOI: 10.1055/s-0031-1289194

Metal-Mediated Synthesis

Pd-Catalyzed Direct Alkynylation of Aliphatic C-H Bonds

Contributor(s): Paul Knochel, Andreas K. Steib
Y. Ano, M. Tobisu*, N. Chatani*
Osaka University, Suita, Japan

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Publication History

Publication Date:
19 October 2011 (online)

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Significance

The first palladium-catalyzed alkynylation of unactivated C(sp^³)-H bonds in aliphatic carboxylic acid derivatives has been disclosed. 8-Aminoquinoline proved to be the best directing group to promote the desired alkynylation reaction.