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Synthesis 2012(5): 767-772
DOI: 10.1055/s-0031-1289709
DOI: 10.1055/s-0031-1289709
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New YorkHighly Effective Synthesis of C-5-Substituted 2′-Deoxyuridine Using Suzuki-Miyaura Cross-Coupling in Water
Further Information
Received
22 November 2011
Publication Date:
14 February 2012 (online)
Publication History
Publication Date:
14 February 2012 (online)
Abstract
An efficient protocol to provide a series of C-5-substituted 2′-deoxyuridine derivatives using a palladium-catalyzed Suzuki-Miyaura cross-coupling reaction in water has been established. Starting from 2′-deoxyuridine derivatives, the target nucleoside analogues were obtained in good yields with low levels of palladium loading without protection of any hydroxyl group of the glycone moiety.
Key words
cross-coupling - Suzuki-Miyaura - nucleosides - green chemistry
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