Synthesis of Chromanes through RCM–Transfer Hydrogenation

Abstract

A sequential ruthenium-catalyzed ring-closing metathesis–transfer hydrogenation sequence has been established as a synthesis of chromanes starting from 2-(allyloxy)styrenes. The sequence requires only one precatalyst, the first-generation Grubbs catalyst, which is converted into a ruthenium hydride species in situ. Propan-2-ol serves as a chemical trigger for the formation of the ruthenium hydride and as hydrogen source.

Key words

ruthenium - chromanes - tandem reactions - metathesis - styrenes

• References

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