A New Approach to the Synthesis of Acyclic Nucleotide Phosphonate Analogues with Triple or Double Bonds

Abstract

On the basis of new methodology to design the phosphonate analogues of nucleotides, the first series of acyclic nucleotides possessing a triple bond in the carbon skeleton were prepared by coupling diethyl 4-chlorobuta-1,2-dienylphosphonate with the corresponding purine or pyrimidine nucleic bases under base-catalyzed alkylation conditions.

Key words

allenes - alkylation - antiviral agents - DNA - heterocycles - hydrogenation - nucleotides - phosphorus

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