Synlett 2012; 23(10): 1546-1548
DOI: 10.1055/s-0031-1291013
letter
© Georg Thieme Verlag Stuttgart · New York

Continuous Flow Synthesis of Secondary Amides by Tandem Azidation– Amidation of Anilines

Christian Spiteri
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK, Fax: +44(115)9513533   Email: john.moses@nottingham.ac.uk
,
John E. Moses*
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK, Fax: +44(115)9513533   Email: john.moses@nottingham.ac.uk
› Author Affiliations
Further Information

Publication History

Received: 20 February 2012

Accepted after revision: 23 March 2012

Publication Date:
29 May 2012 (online)


Abstract

The continuous flow synthesis of a variety of secondary amides by tandem azidation–amidation of anilines is described. This new procedure benefits from the improved safety feature of generating aromatic azides in flow, thus ensuring low concentrations of any potentially hazardous intermediates. The protocol was amenable to the production of multi-gram quantities of the amide product.

Supporting Information

 
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