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Planta Med 2012; 78(6): 589-596
DOI: 10.1055/s-0031-1298265
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Isolation, Structural Elucidation, and Cytotoxicity of Three New ent-Kaurane Diterpenoids from Isodon japonica var. glaucocalyx

Hui-Juan Liang1 , Yun-Xiao Zhang2 , Guang-Fan Hai1 , Su-Ping Bai1 , Yong-Liang Yuan1 , Dan-Dan Ye1 , Nan-Qian Zhou3
  • 1School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, P. R. China
  • 2Department of Chemistry, Zhengzhou University, Zhengzhou, Henan, P. R. China
  • 3Basic Medical Science College, Xinxiang Medical University, Xinxiang, Henan, P. R. China
Further Information

Publication History

received Dec. 8, 2011 revised January 14, 2012

accepted January 22, 2012

Publication Date:
09 February 2012 (online)

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Isolation, Structural Elucidation, and Cytotoxicity of Three New ent-Kaurane Diterpenoids from Isodon japonica var. glaucocalyxPlanta Med 2013; 79(16): 1588-1588
DOI: 10.1055/s-0033-1350998

Abstract

Three new ent-kaurane diterpenoids, glaucocalyxin H (1), glaucocalyxin I (2), and glaucocalyxin J (3), together with four known diterpenoids (4-7), were isolated from the leaves of Isodon japonica Hara var. glaucocalyx. Their structures were elucidated by spectroscopic analysis, and the structures of compounds 2 and 3 were further confirmed by X-ray crystallographic analysis. Compounds 1, 4, and 5 were evaluated for their cytotoxicity in vitro against CE-1, U87, A-549, MCF-7, Hela, K-562, and HepG-2 human tumor cell lines. Compound 1 showed potent inhibitory activities against six tumor cell lines with IC50 values ranging from 1.86–10.95 µM, and compounds 4 and 5 exhibited significant selective cytotoxicity on seven tumor cell lines.

Key words

Labiatae - Isodon japonica Hara var. glaucocalyx - ent-kaurane diterpenoid - cytotoxicity

Supporting Information

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Prof. Dr. Su-Ping Bai

School of Pharmacy
Xinxiang Medical University

Jinsui Avenue East

Xinxiang Henan Province 453003

P. R. China

Phone: +86 0 37 33 02 98 84

Fax: +86 0 37 33 02 98 79

Email: baisuping@xxmu.edu.cn

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