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Planta Med 2012; 78(12): 1387-1391
DOI: 10.1055/s-0032-1314999
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

New Serratene Triterpenoids from Palhinhaea cernua and Their Cytotoxic Activity

Jian Yan
1   Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
,
Zhong-Yu Zhou
1   Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
,
Mei Zhang
1   Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
3   Graduate School of the Chinese Academy of Sciences, Beijing, China
,
Jing Wang
1   Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
3   Graduate School of the Chinese Academy of Sciences, Beijing, China
,
Hao-Fu Dai
2   State Key Laboratory of Tropical Crops Biotechnology, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou, China
,
Jian-Wen Tan
1   Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China
› Author Affiliations
Further Information

Publication History

received 22 February 2012
revised 17 May 2012

accepted 01 June 2012

Publication Date:
29 June 2012 (online)

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Abstract

Four new serratene triterpenoids, 3β,21β,24-trihydroxyserrat-14-en-24-(4′-hydroxybenzoate) (1), 3β,21α,24-trihydroxyserrat-14-en-3-(4′-hydroxybenzoate) (2), 3β,14α,15α,21α-tetrahydroxyserrat-14-en-3-(3′-methoxyl-4′-hydroxybenzoate) (3), and 3β,14α,15α,21α-tetrahydroxyserrat-14-en-21-acetyl-3-(4′-hydroxybenzoate) (4), together with two known ones, 5 and 6, were isolated from whole plants of Palhinhaea cernua. The structures of these new compounds were elucidated by spectroscopic methods. All the six compounds were tested for their in vitro cytotoxicity against three human cancer cell lines (K562, SMMC-7721, and SGC7901). Compound 5 showed cytotoxicity against the three test cell lines with IC50 values of 20.3, 34.0, and 22.5 ug/mL, respectively. Compound 1 showed slight cytotoxicity against K562 cell lines with IC50 value of 56.1 ug/mL, while no obvious inhibitory effects were detected for other compounds.

Key words

Palhinhaea cernua - Lycopodiaceae - serratene - triterpenoid - cytotoxic activity

Supporting Information

 

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