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Planta Med 2012; 78(14): 1591-1596
DOI: 10.1055/s-0032-1315079
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

New Xanthone Glycosides from Comastoma pedunculatum

Yongqi Qiao
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Yi Yuan
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Baosong Cui
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Ying Zhang
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Hui Chen
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Shuai Li
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Yan Li
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 21. Dezember 2011
revised 20. Juni 2012

accepted 25. Juni 2012

Publikationsdatum:
18. Juli 2012 (online)

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Abstract

Five new xanthone glycosides, comastomasides A–E (1–5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1–5 were evaluated for their hepatoprotective activity and cytotoxicity against four human cancer cell lines by in vitro assays. Among them, compounds 3 and 5 exhibited potent hepatoprotective activity. However, none of the compounds displayed cytotoxic activity.

Key words

Comastoma pedunculatum - Gentianaceae - xanthone glycosides - hepatoprotective activity

Supporting Information

 

  • References

  • 1 Fan SF, Hu BL, Ding JY, Sun HF. Study on the chemical constituents of Comastoma pulmonarium (Turcz.) Toyohuni. Acta Bot Sin 1988; 30: 303-307
    PubMedSuche in Google Scholar
  • 2 Tang L, Cui J, Zhou SX. Xanthones from Comastomu pedunculatum . Chem Nat Compd 2009; 45: 733-734
    CrossrefPubMedSuche in Google Scholar
  • 3 El-Seedi HR, El-Barbary MA, El-Ghorab DMJ, Bohlin L, Borg-Karlson AK, Göransson U, Verpoorte R. Recent insights into the biosynthesis and biological activities of natural xanthones. Curr Med Chem 2010; 17: 854-901
    CrossrefPubMedSuche in Google Scholar
  • 4 Nguyen LHD, Harrison LJ. Triterpenoid and xanthone constituents of Cratoxylum cochinchinense . Phytochemistry 1998; 50: 471-476
    PubMedSuche in Google Scholar
  • 5 Zhao PP, Li BM, He LY. Studies on the method of determination of combined sugars in glycosides. Acta Pharm Sin 1987; 22: 70-74
    PubMedSuche in Google Scholar