Antiviral Triterpenoid Saponins from the Roots of Ilex asprella

Abstract

Two new sulfur-containing triterpenoid saponins, asprellanosides A (1) and B (2), were isolated from the roots of Ilex asprella, together with 10 known compounds (3–12). An in vitro anti-HSV-1 activity test of the isolates (1–4, 6–7, and 9–12) showed that only asprellanoside A (1) and oblonganoside H (6) exhibited anti-HSV-1 activity with TIC values of 0.14 and 0.18 mM, respectively.

Key words

Ilex asprella - Aquifoliaceae - sulfur-containing triterpenoid saponins - asprellanosides A and B - antiviral

• References

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