A Phenolic Derivative and Two Diacetylenes from Symphyotrichum subulatum

Abstract

A pytochemical study on the constituents of the roots of Symphyotrichum subulatum led to the isolation of three new compounds including two diacetylenes, asterynes A (1) and B (2), and (E)-4-(3-acetoxyprop-1-enyl)-2-methoxyphenyl (S)-2-methylbutanoate (3) along with twelve known compounds. Their structures were elucidated with spectroscopic analyses. Compound 3 showed anti-inflammatory activity on LPS-induced NO production with an EC₅₀ value of 15.0 µM.

Key words

Symphyotrichum subulatum - Asteraceae - asteryne A - asteryne B - (E)-4-(3-acetoxyprop-1-enyl)-2-methoxyphenyl (S)-2-methylbutanoate - anti-inflammatory

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