Synthesis 2012; 44(22): 3496-3504
DOI: 10.1055/s-0032-1316791
paper
© Georg Thieme Verlag Stuttgart · New York

Synthetic Routes to a Series of Proximal and Distal 2′-Deoxy Fleximers

Orrette R. Wauchope
Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA   Fax: +1(410)4552608   Email: [email protected]
,
Melvin Velasquez
Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA   Fax: +1(410)4552608   Email: [email protected]
,
Katherine Seley-Radtke*
Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA   Fax: +1(410)4552608   Email: [email protected]
› Author Affiliations
Further Information

Publication History

Received: 31 July 2012

Accepted after revision: 10 September 2012

Publication Date:
02 October 2012 (online)


Abstract

Two series of innovative 2′-deoxy nucleoside analogues have been designed where the nucleobase has been split into its imidazole and pyrimidine subunits. This structural modification serves to introduce flexibility into the nucleobase scaffold while still retaining the elements required for recognition. The synthetic efforts to realize these analogues are described within.

 
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