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Synthesis 2012; 44(24): 3815-3821
DOI: 10.1055/s-0032-1317526
DOI: 10.1055/s-0032-1317526
paper
[RuH2(PPh3)4]-Catalyzed Michael Addition Reaction of α-Fluoronitroalkanes
Authors
Further Information
Publication History
Received: 03 September 2012
Accepted after revision: 14 October 2012
Publication Date:
09 November 2012 (online)
Abstract
The Michael addition reactions of α-fluoronitroalkanes with various electron-deficient olefins were realized by catalysis of low-valence ruthenium species through Csp3-H activation, providing a useful way to construct a fluorinated quaternary carbon center. The reactions were carried out under neutral conditions, affording the desired products in moderate to excellent yields.
Key words
Michael addition - fluoronitroalkanes - ruthenium - C-H activation - fluorinated quaternary carbonSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information (PDF)
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