Phytochemical investigation of Rauvolfia nukuhivensis, a Marquesan traditional medicinal plant

Rauvolfia nukuhivensis (Apocynaceae) is an endemic species of the Marquesas archipelago where it is used as a traditional gynecological antiseptic. Over-exploited because of the frequent use of the bark (macerate), the plant is now classsified as an endangered species (“Critical Rare” UICN status). Data regarding pharmacological principles and their chemical identity were not available until now. The phytochemical investigation of the main constituents of this popular medicinal plant resulted in the isolation and identification of several alkaloids belonging to the sandwicine and ajmaline type, among them also formerly unknown derivatives. In order to test the efficacy against human pathogens (Staphylococcus aureus, Escherichia coli and Candida albicans) bioassays were carried out, showing moderate antifungal activities of some compounds.