Rauvolfia nukuhivensis (Apocynaceae) is an endemic species of the Marquesas archipelago where it is used
as a traditional gynecological antiseptic. Over-exploited because of the frequent
use of the bark (macerate), the plant is now classsified as an endangered species
(“Critical Rare” UICN status). Data regarding pharmacological principles and their
chemical identity were not available until now. The phytochemical investigation of
the main constituents of this popular medicinal plant resulted in the isolation and
identification of several alkaloids belonging to the sandwicine and ajmaline type,
among them also formerly unknown derivatives. In order to test the efficacy against
human pathogens (Staphylococcus aureus, Escherichia coli and Candida albicans) bioassays were carried out, showing moderate antifungal activities of some compounds.
