Hexane extract of the seeds oy Byrsonima crassifolia accelerates wound healing in streptozotocin-induced diabetic ratas

Seeds of Byrsonima crassifolia has been shown to possess wound healing activity. Therefore, it may be worthwhile to study the effect of B. crassifolia in diabetic wound healing. Wound healing potential of hexane extract (NS) in the form of simple ointment for treatment of dermal wounds was studied in streptozotocin-induced diabetic rats on excision wound, incision wound and dead space wound. Various parameters as epithelization period, scar area, tensile strength, hydroxyproline, total protein, DNA, hexosamine, uronic acid, antioxidant enzymes (SOD and CAT) were used to evaluate the effect of B. crassifolia on wound healing. NS in form topical accelerates the wound healing process by decreasing the surface area of the wound with a significant increase in the rate of wound contraction and tensile strength. Increase granulation tissue dry weight, hydroxyproline, total protein, DNA and SOD and CAT when compared to diabetic control. Our results demonstrated for the first time that Byrsonima crassifolia was effective in promoting diabetic wound healing in rats through the processes of tissue regeneration.