Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

CS Funari; FP Gullo; A Napolitano; RL Carneiro; MJSM Giannini; AMF Almeida; S Piacente; C Pizza; DHS Silva

doi:10.1055/s-0032-1321106

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Planta Med 2012; 78 - PI419
DOI: 10.1055/s-0032-1321106

Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil

CS Funari ¹, FP Gullo ², A Napolitano ³, RL Carneiro ⁴, MJSM Giannini ², AMF Almeida ², S Piacente ³, C Pizza ³, DHS Silva ¹

¹Department of Organic Chemistry, Institute of Chemistry, São Paulo State University, Araraquara, Brazil
²School of Pharmaceutical Sciences, Araraquara
³Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Fisciano, Italy
⁴Federal University of São Carlos, Department of Chemistry, São Carlos, SP, Brazil

Congress Abstract

Lippia genus is used in ethnobotany as food, beverages, seasoning and remedies for antiseptic and anti-inflammatory purposes, among others. Chemical compositions of fifteen extracts of six Lippia species were investigated comparatively by HPLC-PDA. To avoid data replication, L. lupulina Cham. roots EtOH extract was selected for isolation procedures based on PCA analyses of previous works on this genus. Seven compounds previously unreported in this genus were isolated. The bioactivity of extracts, fractions and pure compounds were investigated towards Candida albicans, C. krusei, C. parapsilosis and Cryptococcus neoformans strains. Fractions from the EtOH extract of L. salviaefolia leaves showed marked inhibition of fungal growth, in addition to asebogenin (1) and verbascoside (2) which showed MIC values lower than 15,6µg/mL and might be considered as promising prototypes for the development of new antifungal agents, especially against C. neoformans. Acknowledgements: FAPESP, CAPES and CNPq.