Comparative metabolomic fractionation and characterization of licorice roots

C Simmler; D Nikolic; RB van Breemen; DC Lankin; SN Chen; GF Pauli

doi:10.1055/s-0032-1321242

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Planta Med 2012; 78 - PJ82
DOI: 10.1055/s-0032-1321242

Comparative metabolomic fractionation and characterization of licorice roots

C Simmler ¹, D Nikolic ¹, RB van Breemen ¹, DC Lankin ¹, SN Chen ¹, GF Pauli ¹

¹UIC/NIH Center for Botanical Dietary Supplements Research & Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago College of Pharmacy, 833 S. Wood St., Chicago, IL 60612 USA

Congress Abstract

Glycyrrhiza glabra L. and G. uralensis Fisch. (Fabaceae) are the most widely used licorice species. Despite their chemical similarities, each species is defined by the presence of a broad range of secondary metabolites found in trace amounts. For our aim, which is directed toward their exhaustive metabolomic characterization, a 3-step fractionation map (see figure) has been developed, combining reproducible medium-pressure liquid and countercurrent chromatografies (MPLC and CCC). Each technique associated with a type of licorice marker, was selected for its high recovery. An in-house spectral database has been compiled to foster extended metabolomic studies of licorice samples.