Isolation and cytotoxic activity of some secoiridoids from Gentiana olivieri

F Yalçın; S Meydan; D Kaya; Y Genç; Ş Harput; T Ersöz

doi:10.1055/s-0032-1325175

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Planta Med 2012; 78 - PL33
DOI: 10.1055/s-0032-1325175

Isolation and cytotoxic activity of some secoiridoids from Gentiana olivieri

F Yalçın ¹, S Meydan ², D Kaya ¹, Y Genç ¹, Ş Harput ¹, T Ersöz ¹

¹Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100 Sıhhiye, Ankara, Turkey
²Faculty of Pharmacy (Undergraduate Student), Hacettepe University, 06100 Sıhhiye, Ankara

Congress Abstract

The genus Gentiana (Gentianaceae) is represented by 12 species in Turkish Flora with important biological effects such as antipyretic, stomachic, antidepressant, anticonvulsant, hepatoprotective and antidiabetic activities. Iridoids, secoiridoids, C-glycosylflavones and xanthones are considered to be the most promising groups of compounds responsible for the pharmacological activities of the Gentiana species. In this study swertiamarin, sweroside and gentiopicroside were isolated from Gentiana olivieri and their cytotoxic activities were evaluated against HEP-2 (human larynx epidermoid carcinoma) cell lines based on MTT assay for growth inhibition.