Am J Perinatol 2013; 30(06): 451-462
DOI: 10.1055/s-0032-1326990
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Environmental Risk Factors and Perinatal Outcomes in Preterm Newborns, According to Family Recurrence of Prematurity

Hugo B. Krupitzki
1   Dirección de Investigación, CEMIC (Centro de Educación Médica e Investigaciones Clínicas), Buenos Aires, Argentina
Enrique C. Gadow
1   Dirección de Investigación, CEMIC (Centro de Educación Médica e Investigaciones Clínicas), Buenos Aires, Argentina
Juan A. Gili
2   ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at CEMIC, Buenos Aires, Argentina
Belén Comas
2   ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at CEMIC, Buenos Aires, Argentina
Viviana R. Cosentino
2   ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at CEMIC, Buenos Aires, Argentina
César Saleme
3   Maternidad Nuestra Señora de la Merced, Tucumán, Argentina
Jeffrey C. Murray
4   Department of Pediatrics, University of Iowa, Iowa
Jorge S. Lopez Camelo
2   ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at CEMIC, Buenos Aires, Argentina
5   IMBICE (Instituto Multidisciplinario de Biologia Celular), La Plata, Buenos Aires, Argentina
6   INAGEMP (Instituto Nacional de Genética Médica Populacional) at Laboratório de Epidemiologia de Malformações Congênitas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
› Author Affiliations
Further Information

Publication History

07 March 2012

14 June 2012

Publication Date:
06 November 2012 (online)


Objective We analyzed the role of environmental risk factors, sociodemographic characteristics, clinical characteristics, and reproductive history in preterm births and their associated perinatal outcomes in families classified according to their histories of preterm recurrence among siblings.

Study Design A retrospective study was conducted at Nuestra Señora de la Merced Maternity Hospital in the city of Tucumán, Argentina. A total of 348 preterm, nonmalformed, singleton children born to multipara women were reviewed. The family history score described by Khoury was applied, and families were classified as having no, medium, or high genetic aggregation.

Results Families with no familial aggregation showed a higher rate of short length of cohabitation, maternal urinary tract infections during the current pregnancy, and maternal history of miscarriage during the previous pregnancy. Families with a high level of aggregation had a significantly higher incidence of pregnancy complications, such as diabetes, hypertension, and immunologic disorders.

Conclusion Reproductive histories clearly differed between the groups, suggesting both a different response to environmental challenges based on genetic susceptibility and the activation of different pathophysiological pathways to determine the duration of pregnancy in each woman.

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