Planta Med 2013; 79(05): 348-352
DOI: 10.1055/s-0032-1328260
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

New Flavonol and Diterpenoids from the Endophytic Fungus Aspergillus sp. YXf3

Tong Yan
1  Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Zhi Kai Guo
1  Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Rong Jiang
1  Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Wei Wei
1  Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Ting Wang
1  Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Ye Guo
1  Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Yong Chun Song
1  Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Rui Hua Jiao
1  Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Ren Xiang Tan
1  Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
,
Hui Ming Ge
1  Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China
› Author Affiliations
Further Information

Publication History

received 24 July 2012
revised 15 January 2013

accepted 22 January 2013

Publication Date:
01 March 2013 (eFirst)

Abstract

One new flavonol, chlorflavonin A (1), four new diterpenoids, aspergiloids E–H (3, 57), together with eight known compounds (2, 4, 813) were isolated from solid fermentation of Aspergillus sp. (strain no. YXf3), an endophytic fungus from Ginkgo biloba. Their structures were determined through detailed spectroscopic analysis combined with comparison of NMR spectra data with reported ones. All of them were screened on cytotoxicity against KB, SGC-7901, SW1116, and A549 cell lines; compounds 4, 911 exhibited moderate activities with IC50 values ranging from 6.74 to 46.64 µM.

Supporting Information