Planta Med 2013; 79(05): 361-364
DOI: 10.1055/s-0032-1328286
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Phenolic Constituents from the Twigs of Euonymus alatus and Their Cytotoxic and Anti-inflammatory Activity

Ki Hyun Kim
1  Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea
,
Sang Keun Ha
2  Korea Food Research Institute, Sungnam, Korea
,
Sang Un Choi
3  Korea Research Institute of Chemical Technology, Daejeon, Korea
,
Sun Yeou Kim
4  College of Pharmacy, Gachon University, Incheon, Korea
,
Kang Ro Lee
1  Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, Korea
› Author Affiliations
Further Information

Publication History

received 14 November 2012
revised 24 January 2013

accepted 30 January 2013

Publication Date:
06 March 2013 (eFirst)

Abstract

A bioassay-guided fractionation and chemical investigation of the MeOH extract of the twigs of Euonymus alatus resulted in the isolation and identification of five new phenolic compounds, named alatusols A−E (15), together with six known compounds (611). The structures of these new compounds were elucidated through spectral analysis, including extensive 2D-NMR data, and their absolute configurations were determined by the modified Mosherʼs method. Compounds 13 and 79 showed consistent cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines with IC50 values of 15.20–29.81 µM. In addition, compounds 5 and 7 inhibited nitric oxide production in lipopolysaccharide-activated BV-2 cells with IC50 values of 22.77 and 32.52 µM, respectively.

Supporting Information