Antiproliferative Triterpenoid Saponins from the Stem of Psychotria sp.

Abstract

Six new triterpenoid saponins, psychotrianosides A–F (1–6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1–8 against five human cancer cell lines (MDA-MB-231, MCF-7, MCF-7/ADM, HepG2, and HepG2/ADM) are reported for the first time. Psychotrianoside C (3) showed the most potent antiproliferative activity among these saponins, and the IC₅₀ value of 3 against MDA-MB-231 was 2.391 ± 0.161 µM. Compound 3 was also found to induce apoptosis.

Key words

Rubiaceae - Psychotria sp. - triterpenoid saponins - antiproliferative

^* These authors contributed equally to this work.

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