Eur J Pediatr Surg 2014; 24(02): 174-178
DOI: 10.1055/s-0033-1333634
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Surgical Stress after Open and Transumbilical Laparoscopic-Assisted Appendectomy in Children

Pietro Impellizzeri
1   Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy
,
Angela Simona
1   Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy
,
Maria Grasso
2   Unit of Genetic and Pediatric Immunology, Department of Pediatric, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy
,
Pietro Antonuccio
1   Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy
,
Caterina Crisafi
3   Unit of Anesthesiology, University of Messina, Messina, Italy
,
Gianfranco Scalfari
1   Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy
,
Francesco Arena
1   Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy
,
Carmelo Salpietro
2   Unit of Genetic and Pediatric Immunology, Department of Pediatric, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy
,
Mario Lima
4   Unit of Pediatric Surgery, University of Bologna, Bologna, Italy
,
Carmelo Romeo
1   Unit of Pediatric Surgery, Department of Pediatrics, Gynecological, Mycrobiological, and Biomedical Sciences, University of Messina, Messina, Italy
› Author Affiliations
Further Information

Publication History

16 August 2012

08 December 2012

Publication Date:
26 February 2013 (online)

Abstract

Introduction The transumbilical laparoscopic-assisted appendectomy (TULAA) effects on the surgical stress response in children have not been studied. Our aim is to investigate the stress response in TULAA.

Methods A total of 35 children underwent the appendectomy by open approach (OA) or TULAA approach. Interleukins (ILs)-6, -18, and -10 were measured before (T0), at the beginning (T1a), and at the end of surgery (T1b) and 24 hours after (T2).

Results An increase in IL-6 levels at T1b and T2 and in IL-18 at T2 was observed after OA. A significant increase of both IL-6 and IL-18 were observed at T2 but values were less compared with OA (11.6 ± 4.4 vs. 31.9 ± 8.9 pg/mL for IL-6, p = 0.0006; 145.6 vs. 174.9 pg/mL for IL-18, p = NS).

Conclusions A significant reduction in the postoperative cytokines in TULAA group suggests that this approach causes less surgical trauma in children.

 
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