Asymmetric Transfer Hydrogenation of 3-(Trifluoromethyl)quinolines

Abstract

A chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-(trifluoromethyl)quinolines was successfully developed with up to 98% ee. The new method provides a direct and facile access to chiral 2,3-disubstituted 1,2,3,4-tetrahydroquinoline derivatives containing a stereogenic trifluoromethyl group.

Key words

chiral phosphoric acid - transfer hydrogenation - quinolines - trifluoromethyl group

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• 17 CCDC 998021 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge at www.ccdc.cam.ac.uk/conts/retrieving.html or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: [phone]; E-mail: [e-mail].