Synthesis 2014; 46(07): 933-942
DOI: 10.1055/s-0033-1340734
paper
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Cross-Coupling between 8-Substituted 6-Thiophenyl­purines and Boronic Acids

Roxane Vabre
a  Univ Paris-Sud, 91405 Orsay, France
b  UMR 176, Institut Curie/CNRS, Bât 110 Centre Universitaire, 91405 Orsay, France   Fax: +33(1)69075381   Email: sandrine.piguel@curie.fr
,
Julien Couradin
a  Univ Paris-Sud, 91405 Orsay, France
b  UMR 176, Institut Curie/CNRS, Bât 110 Centre Universitaire, 91405 Orsay, France   Fax: +33(1)69075381   Email: sandrine.piguel@curie.fr
,
Delphine Naud-Martin
b  UMR 176, Institut Curie/CNRS, Bât 110 Centre Universitaire, 91405 Orsay, France   Fax: +33(1)69075381   Email: sandrine.piguel@curie.fr
,
Michel Legraverend
b  UMR 176, Institut Curie/CNRS, Bât 110 Centre Universitaire, 91405 Orsay, France   Fax: +33(1)69075381   Email: sandrine.piguel@curie.fr
,
Sandrine Piguel*
a  Univ Paris-Sud, 91405 Orsay, France
b  UMR 176, Institut Curie/CNRS, Bât 110 Centre Universitaire, 91405 Orsay, France   Fax: +33(1)69075381   Email: sandrine.piguel@curie.fr
› Author Affiliations
Further Information

Publication History

Received: 14.11. 2013

Accepted after revision: 12 January 2014

Publication Date:
11 February 2014 (eFirst)

Abstract

A palladium(II)-catalyzed, copper(I)-mediated ­Liebeskind–Srogl cross-coupling for the C-6 arylation/alkenylation on purine scaffold is reported. Various boronic acids reacted readily with 8-substituted 6-thiophenylpurines.

Supporting Information

 
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