One-Pot Parallel Synthesis Approach to Secondary Amines Based on the Reductive Amination of Ketones

Abstract

A combination of a condensation mixture [a Lewis acid, Ti(Oi-Pr)₄, and a water scavenger, 1-(trimethylsilyl)-2-pyrrolidinone] and a simple reductant (NaBH₄) provides an efficient one-pot approach to parallel synthesis of secondary amines by the reductive amination of ketones. The approach demonstrated its applicability to a variety of substrates with different degree of hindrance of an amino or a carbonyl group affording products in moderate to high yields.

Key words

combinatorial chemistry - one-pot approach - parallel synthesis - reductive amination - secondary amines

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