Subscribe to RSS
DOI: 10.1055/s-0033-1352110
Bioactive constituents from Pteris ensiformis
Pteris ensiformis Burm. is a perennial herb, distributed in South China, India, Malay Peninsula, South Japan, Ryukyu Islands, the Philippines, Tropical Australia, and Taiwan. The genus Pteris (Pteridaceae) comprises about 300 species with tropical distribution. Various sesquiterpenes, flavonoids, benzenoids, and their derivatives are widely distributed in plants of genus Pteris. Many of these compounds exhibit cytotoxic, antioxidant, and antidiabetic activities. Investigation of the EtOAc-soluble fraction of the whole plants of P. ensiformis has led to the isolation of a new pterosin sesquiterpene, (R)-4-O-methylangolensin (1), along with 5 known compounds. The structure of 1 was determined through extensive 1D/2D NMR and mass-spectrometric analyses. Among the isolated compounds, (2S,3S)-13-hydroxypterosin T exhibited antitubercular activities (MIC = 6.25 µg/ml) against Mycobacterium tuberculosis H37Rv in vitro. Acknowledgement: This research was supported by grants from the National Science Council (NSC, Taiwan) (No. NSC 98 – 2320-B-127 – 001-MY3 and NSC 101 – 2320-B-127 – 001-MY3), awarded to Prof. J.-J. Chen.