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Planta Med 2013; 79 - PI64
DOI: 10.1055/s-0033-1352153
DOI: 10.1055/s-0033-1352153
Trichophenols A-D, four novel phenolic ethers from the fermented broths of Trichobotrys effusa YMJ1179
Four novel phenolic ethers, namely trichophenols A-D (1-4), were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of 1-4 were elucidated based on spectroscopic data analyses. The absolute configuration of 1 was determined by modified Mosher's method. Compounds 1-4 exhibited moderate growth inhibitory activity against A549 lung cancer line with GI50 values of 25.6, 19.3, 16.2 and 24.3µM, respectively. Moreover, 1 exhibited moderate growth inhibitory activity against TOV-21G-Tx paclitaxel-resistant ovarian cancer cell line with a GI50 value of 21.3µM.