Planta Med 2013; 79 - PI64
DOI: 10.1055/s-0033-1352153

Trichophenols A-D, four novel phenolic ethers from the fermented broths of Trichobotrys effusa YMJ1179

H Hsiao 1, C Hsiao 2, S Wang 3, Y Ju 4, Y Kuo 5, T Lee 6
  • 1Graduate Instutute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan
  • 2School of Respiratory Therapy, Taipei Medical University, Taipei, Taiwan
  • 3Department of Medicine, Mackay Medical University, New Taipei City, Taiwan
  • 4Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan
  • 5Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung, Taiwan
  • 6Graduate Institute of Pharmacognosy, Taipei Medical University, TaiPei, Taiwan

Four novel phenolic ethers, namely trichophenols A-D (1-4), were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of 1-4 were elucidated based on spectroscopic data analyses. The absolute configuration of 1 was determined by modified Mosher's method. Compounds 1-4 exhibited moderate growth inhibitory activity against A549 lung cancer line with GI50 values of 25.6, 19.3, 16.2 and 24.3µM, respectively. Moreover, 1 exhibited moderate growth inhibitory activity against TOV-21G-Tx paclitaxel-resistant ovarian cancer cell line with a GI50 value of 21.3µM.

Fig. 1