Horsfiequinones A–F, Dimeric Diarylpropanoids from Horsfieldia tetratepala

Abstract

A new diarylpropanoid, horsfiequinone A (1), and five new dimeric diarylpropanoids with 1,4-p-benzoquinone residue, horsfiequinones B–F (2–6), along with a known compound, combrequinone B (7), were isolated from Horsfieldia tetratepala. Their structures were elucidated by means of spectroscopic analysis. Horsfiequinones B–F (2–6), isolated as enantiomer mixtures with unequal proportions, were verified by analysis on a chiral OD-H HPLC column. Cytotoxicity evaluation against five human tumor lines showed selective inhibitory effects on HL-60 for several compounds tested with IC₅₀ values ranging from 3.18 ± 0.67 to 6.61 ± 0.08 µM.

Key words

Horsfieldia tetratepala - Myristicaceae - diarylpropanoid - cytotoxicity

• References

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